Allele/Variant

Pdgfrbtm4Sor

Species
Mus musculus
Symbol
Pdgfrbtm4Sor
Category
allele
Allele of gene
Pdgfrb
Transgenic Constructs
None
Synonyms
  • F3
Description
A to T transversions in the sequences corresponding to codons 739 and 750 were introduced that altered the corresponding amino acids from tyrosine to phenylalanine (Y739F, Y750F). In addition, a mutation was introduced that altered the sequences of the codon corresponding to amino-acid 1020 from a tyrosine to an isoleucine (Y1020I) (DNA alteration not specified). These mutations are predicted to disrupt the PI3-K and PLC-gamma binding sites in the protein. A loxP flanked neomycin cassette was inserted into an adjacent intron. Removal of this neomycin cassette had no effect on the phenotype, and analysis of mice with or without the neomycin casstte was not distinguished in the paper.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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