Fgfr3^tm2Wei

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Species

Mus musculus

Symbol

Fgfr3^tm2Wei

Category

allele

Allele of gene

Fgfr3

Transgenic Constructs

None

Synonyms

• Fgfr3^G374R
• FGFR3^G374Rneo-

Description

Introduction of a G to A point mutation in codon 374 (orthologous to human codon 380) that altered the corresponding amino acid from a glycine to an arginine. A loxP flanked neomycin cassette inserted into intron 4 was removed by cre-mediated recombination. Northern blot analysis revealed that a normal molecular weight mRNA was made in homozygous mutants.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations