Allele/Variant

Vhltm1Jae

Species
Mus musculus
Symbol
Vhltm1Jae
Category
allele
Allele of gene
Vhl
Transgenic Constructs
None
Synonyms
  • 2-lox allele
  • VHL+f
Description
A CMV-hyTK selection cassette flanked by two loxP sites was inserted approximately 2.6 kb upstream of exon 1. A third loxP site was inserted into intron 1. The hygromycin cassette was deleted in ES cells by transient transfection with a vector driving expression of Cre recombinase. The resulting ES cell derivatives with two loxP sites flanking exon 1 were selected and injected into blastocysts to generate the Vhltm1Jae allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations