Nf1^tm1Cbr

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Species

Mus musculus

Symbol

Nf1^tm1Cbr

Category

allele

Allele of gene

Nf1

Transgenic Constructs

None

Synonyms

• Nf1^23a-

Description

A neomycin resistance cassette replaced 300 bp of genomic DNA including exon 23a. RT-PCR analysis of brain detected neurofibromin type I but not the type II isoform in homozygous mutant mice. Western blot analysis detected the type I but not the type II neurofibronin in brain of homozygous mutant mice. Immunohistochemical analysis of brain did not detect type II neurofibromin isoform in homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations