Apoe^tm1Bres

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Species

Mus musculus

Symbol

Apoe^tm1Bres

Category

allele

Allele of gene

Apoe

Transgenic Constructs

None

Synonyms

• apo E-
• apoE^-

Show All 4

Description

A neomycin resistance cassette replaced 1.4kb of the gene, including part of the promoter through part of the second intron. Northern blot analysis using a mouse exon 4 riboprobe did not detect wild-type message in livers from homozygous mutant mice, but did detect a longer transcript that the authors propose is a neo-Apoe fusion product. Gradient SDS-PAGE analysis did not detect full size Apoe associated with any fractions from plasma lipoproteins from homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations