Tnc^tm1Sia

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Species

Mus musculus

Symbol

Tnc^tm1Sia

Category

allele

Allele of gene

Tnc

Transgenic Constructs

None

Synonyms

• TN-

Description

A lacZ gene and neomycin resistance cassette were inserted into exon 2, just before the translation initiation codon. Two thirds of exon 2 and a part of intron 2 were deleted. This allele expresses beta-galactosidase under the control of the endogenous promoter. Northern analysis demonstrated that homozygous mice did not express wild-type mRNA. Immunohistochemistry on thymus, lung and cerebellum failed to detect wild-type protein in homozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations