Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Snrpntm2Cbr
- Species
- Mus musculus
- Symbol
- Snrpntm2Cbr
- Category
- allele
- Allele of gene
- Snrpn
- Transgenic Constructs
- None
- Synonyms
- deltaPWS-IC
- IC deletion
- Description
- A neomycin resistance gene cassette replaced 42 kb of sequence encompassing 23 kb upstream of the gene and Snrpn exons 1-6. Unintentionally, the neo gene and several kb of flanking endogenous sequence (from upstream of Snrpn) was amplified four-fold at the insertion site. Northern blot analysis of brain tissue using a cDNA probe for the gene did not detect any transcript in heterozygous mutant mice. The deleted upstream sequence includes Prader-Willi syndrome imprinting center PWS-IC Rr346 and Angelman syndrome imprinting center AS-IC Rr70.
- Additional Information
- Literature