Chrm2^tm1Jwe

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Species

Mus musculus

Symbol

Chrm2^tm1Jwe

Category

allele

Allele of gene

Chrm2

Transgenic Constructs

None

Synonyms

• M2 KO
• M2^-

Show All 4

Description

A genomic fragment corresponding to sequences encoding the N terminus of the third transmemebrane region to the C terminus of the third intracellular loop was replaced with a neomycin resistance cassette. In situ hybridization experiments demonstrated that no transcript was detectable in brain tissue of homozygous mice. In addition, mutant hearts were unable to bind significant amounts of the muscarinic radioligand [3H]QNB, and muscarinic agonist-induced bradycardia was no longer observed.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations