Adam3^tm1Ihgg

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Species

Mus musculus

Symbol

Adam3^tm1Ihgg

Category

allele

Allele of gene

Adam3

Transgenic Constructs

None

Synonyms

• Cyrn -

Description

A genomic fragment containing exon 3 was replaced with a neomycin selection cassette in opposite transcriptional orientation to the gene. RT-PCR analysis detected the presence of a trancript that spliced exon 2 to 4, but this mutation introduces a frameshift and premature stop codon. Western blots on testicular extracts confirmed the absence of the full length protein in homozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations