Il12rb2^Ifnm-d

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Species

Mus musculus

Symbol

Il12rb2^Ifnm-d

Category

allele

Allele of gene

Il12rb2

Transgenic Constructs

None

Synonyms

• Ifnm

Description

The defective IL-12 response in C57BL/10ScCr mice has been attributed to a point mutation in the Il12rb2 gene. The substitution of a C to G at coding nucleotide 2331 creates a premature stop codon at tyrosine amino acid position 778 (p.Y778*). The resulting truncated protein lacks the C-terminal 96 amino acids of cytosplasmic domain.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations