Bcl2l11^tm1.1Ast

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Species

Mus musculus

Symbol

Bcl2l11^tm1.1Ast

Category

allele

Allele of gene

Bcl2l11

Transgenic Constructs

None

Synonyms

• bim-

Description

Insertion of a floxed PGK-neomycin cassette deleted the exon encoding the BH3 domain. Cre-mediated recombination in vivo subsequently removed the inserted cassette. In the final allele a single loxP site remains in place of the exon. Immunoblot analysis using a rat monoclonal antibody did not detect full-length protein, but did detect a small amount of a truncated polypeptide in spleen cells from homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations