Atp7b^tm1Tcg

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Species

Mus musculus

Symbol

Atp7b^tm1Tcg

Category

allele

Allele of gene

Atp7b

Transgenic Constructs

None

Synonyms

• Atp7b-
• ATPB7-

Description

A genomic fragment containing part of exon 2 was replaced with a neomycin selection cassette. RT-PCR analysis indicated that an abnormal transcript is made from this allele that splices exon 1 to exon 3. This abnormal splicing pattern is predicted to result in a frameshift mutation. Western blot analysis on brain extracts derived from homozygous mice demostrated that no stable full length protein is produced from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations