Allele/Variant

Mbtm1Wlm

Species
Mus musculus
Symbol
Mbtm1Wlm
Category
allele
Allele of gene
Mb
Transgenic Constructs
None
Synonyms
  • Mb-
  • myoglobin -
Description
A neomycin selection cassette replaced a genomic fragment containing exon 2, which encodes the haem-binding domain. RT-PCR analysis on RNA derived from hearts of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot and immunohistochemical analyses confirmed that no stable protein was made from this allele in cardiac tissue of homozygous mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations