Hoxb8^tm1.1Mrc

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Species

Mus musculus

Symbol

Hoxb8^tm1.1Mrc

Category

allele

Allele of gene

Hoxb8

Transgenic Constructs

None

Synonyms

• Hoxb8^lox

Description

Insertion of a floxed neomycin resistance cassette into the second exon introduced a premature translation stop codon into the open reading frame. Pronuclear injection of pMC1-Cre into fertilized eggs carrying the Hoxb8^tm1Mrc allele removed the neo cassette, leaving a single loxP site in the second exon. RT-PCR studies of brain detected a longer transcript produced by this allele than by the wild-type allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations