Mapk14^tm1Nbr

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Species

Mus musculus

Symbol

Mapk14^tm1Nbr

Category

allele

Allele of gene

Mapk14

Transgenic Constructs

None

Synonyms

• p38alpha -

Description

An internal 2 kb genomic fragment was replaced with a lacZ gene and a PGK-neomycin cassette. The deleted region contains two exons encoding amino acids 40-103, which includes most of the amino-terminal lobe of the catalytic domain including the glycine-rich ATP binding loop. Western blot analysis of lysates prepared from E10.5 embryos confirmed that no detectable protein was expressed from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations