Kit^tm1.1Bsm

---

Species

Mus musculus

Symbol

Kit^tm1.1Bsm

Category

allele

Allele of gene

Kit

Transgenic Constructs

None

Synonyms

• kit^Y719F

Description

This allele is a derivative of Kit^tm1Bsm in which a Cre mediated recombination event removed the neomycin cassette. Excision of the neomycin cassette restores normal Kit expression. The resulting heritable mutation, Y719F, was designed to prevent the binding of SH2 domain proteins including the p85 subunit of the PI 3-kinase and to abolish subsequent signaling events.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations