Allele/Variant

Crhr1tm1Wrst

Species
Mus musculus
Symbol
Crhr1tm1Wrst
Category
allele
Allele of gene
Crhr1
Transgenic Constructs
None
Synonyms
  • CRF1 KO
  • Crhr1 -
Description
A neomycin resistance cassette replaced a 3.1 kb genomic fragment containing sequences encoding transmembrane domains 4-7, including the G-coupling protein domain and the intracellular cytoplasmic tail. Extracellular field potential measurements in the CA1 region of the hippocampus confirmed disruption of CRH signal transduction: application of CRH increased the population spike amplitudes in CA1 slices of wild-type mice, but not in slices of homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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