Slit1^tm1.1Matl

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Species

Mus musculus

Symbol

Slit1^tm1.1Matl

Category

allele

Allele of gene

Slit1

Transgenic Constructs

None

Synonyms

• Slit1-

Description

The floxed neo cassette was excised from Slit1^tm1Matl via in vivo cre mediated recombination, leaving the endogenous locus disrupted by a cassette containing an endoplasmic reticulum KDEL retention sequence, a stop codon, and an IRES-tauGFP fusion protein. The initial insertion of the cassette replaced sequence encoding a portion of the second leucine rich repeat. In situ hybridization studies using a 3' antisense probe did not detect mRNA in the ventral spinal cord of homozygous mutant E11.5 embryos.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations