Allele/Variant

Ank2tm1Bnt

Species
Mus musculus
Symbol
Ank2tm1Bnt
Category
allele
Allele of gene
Ank2
Transgenic Constructs
None
Synonyms
  • ABe22*
  • AnkyrinB -
Description
A neomycin resistance gene, an in-frame HA epitope and a stop codon were inserted into exon 22, which encodes the spectrin binding domain. Northern blot analysis on RNA derived from homozygous brains demonstrated that no detectable transcript was expressed from this allele. Western blot analysis on homogenates of homozygous brain confirmed that no encoded protein was present. Nonsense-mediated decay leads to a reduction in the 220-kDa and giant Ank2 polypeptides.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page