Allele/Variant

Acp5tm1Ahdm

Species
Mus musculus
Symbol
Acp5tm1Ahdm
Category
allele
Allele of gene
Acp5
Transgenic Constructs
None
Synonyms
  • Acp5-
  • TRACP-
Description
Exon 2, which encodes the conserved putative iron-binding domain, was disrupted by the insertion of a neomycin resistance gene. Acid phosphatase activity specific to this osteoclast isozyme was assayed and found to be undetectable in bone homogenates from homozygous mutant mice. Further analysis using histochemical staining confirmed the absence of a functional enzyme.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations