Allele/Variant

Adcyap1r1tm1Bbt

Species
Mus musculus
Symbol
Adcyap1r1tm1Bbt
Category
allele
Allele of gene
Adcyap1r1
Transgenic Constructs
None
Synonyms
  • PAC1-
Description
A neomycin selection cassette replaced a 2.3-kb fragment containing exons 8 through 11. The neo gene was situated in the reverse transcriptional orientation and was excised during the splicing of the transcript, resulting in a frameshift that introduces a stop codon in exon 12. A truncated transcript was observed by RT-PCR analysis. A 90% decrease in binding of a radio-labeled ligand in homozygous mutants was observed versus wild-type, as well as an absence of cAMP production stimulation.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations