Arg2^tm1Weo

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Species

Mus musculus

Symbol

Arg2^tm1Weo

Category

allele

Allele of gene

Arg2

Transgenic Constructs

None

Synonyms

• argII^mut

Description

A neomycin resistance gene under the control of an RNA polymerase II promoter replaced portions of exons 4 and 5. The insertion resulted in a frameshift that ablated the enzymatic activity of the protein product in the kidneys of homozygous mutant mice. The enzymatic activity was higher than expected in heterozygous animals but the authors noted a large statistical variation.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations