Atp2a3^tm1Ges

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Species

Mus musculus

Symbol

Atp2a3^tm1Ges

Category

allele

Allele of gene

Atp2a3

Transgenic Constructs

None

Synonyms

• SERCA3^-

Description

A neomycin resistance gene was inserted into exon 5, which encodes amino acids 109 through 154. Northern blot analysis of RNA isolated from colon, lung, and aorta tissue showed the presence of a shortened transcript in homozygous mutant mice. Sequence analysis of the mutant message identified a cryptic donor site in exon 5 that led to the excision of 84 nucleotides encoding amino acids 127 through 154. Transfection of microsomes, showed that the mutant protein product was incapable of calcium-uptake.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations