Allele/Variant

Capn1tm1Ahc

Species
Mus musculus
Symbol
Capn1tm1Ahc
Category
allele
Allele of gene
Capn1
Transgenic Constructs
None
Synonyms
  • Capn-
Description
A PGK-neo cassette replaced the portion of exon 4 encoding amino acids 153 through 160, part of an essential catalytic domain. Expression analysis of homozygous mutant mice showed an absence of normal transcript and additionally that alternate trancripts were not produced by cryptic splicing. Western analysis revealed a lack of protein in homozygous mutants, while casein zymography did not detect calpain activity in platelets.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations