Cbl^tm1Ddlb

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Species

Mus musculus

Symbol

Cbl^tm1Ddlb

Category

allele

Allele of gene

Cbl

Transgenic Constructs

None

Synonyms

• c-Cbl^-

Description

The insertion of a PGK-neo cassette disrupted the exon encoding the phosphotyrosine binding (PTB) domain. Western blot analysis confirmed an absence of normal protein product in homozygous mutant mice. The presence of a truncated protein was noted and determined to be the result of an in-frame splicing event in which the targeted exon was deleted, thus all peptides produced from targeted alleles lacked the conserved residues within the PTB domain.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations