Socs3^tm1Wsa

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Species

Mus musculus

Symbol

Socs3^tm1Wsa

Category

allele

Allele of gene

Socs3

Transgenic Constructs

None

Synonyms

• SOCS3^-

Description

The entire coding region was replaced with a construct containing lacZ and neo. The lacZ was inserted immediately after the start codon, and thus placed under control of the endogenous promoter. Northern blot analysis revealed a lack of transcript in fibroblasts isolated from homozygous mutant embryos stimulated by IFN-gamma. An absence of expression was further confirmed by RT-PCR analysis of total embryonic RNA. The lacZ expression pattern was observed to be the same in whole mount homozygous embryos as it was in heterzygotes.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations