Clcn5^tm1Gug

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Species

Mus musculus

Symbol

Clcn5^tm1Gug

Category

allele

Allele of gene

Clcn5

Transgenic Constructs

None

Synonyms

• ClC-5 KO
• Clcn5 KO

Show All 3

Description

A duplicate of exon 6, which encodes the third and fourth transmembrane domains, was disrupted by a PGK-neo cassette, and inserted into intron 5. Transcript was not detected in the kidneys of homozyous or hemizygous mutant mice by Northern blot analysis. Western blot analysis of renal extracts showed an absence of protein in hemizygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations