Allele/Variant

Itgb4tm1Fgg

Species
Mus musculus
Symbol
Itgb4tm1Fgg
Category
allele
Allele of gene
Itgb4
Transgenic Constructs
None
Synonyms
  • Beta4TL
Description
A cassette containing a stop codon, a SV40 polyadenylation site, and a neomycin resistance gene was inserted immediately downstream of the exon encoding the transmembrane domain (upstream of sequence encoding the cytoplasmic domain). Expression analyses showed the presence of truncated transcript and protein in mutant mice. While Northern blot analysis detected increased levels of mutant transcript, Western blot analysis showed protein levels to be comprable to wild-type. FACS analysis confirmed that mutant protein was correctly expressed on the cell surface.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations