Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
- Species
- Mus musculus
- Symbol
- Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- BDC-2.5/N TCR Tg
- BDC2.5
- Description
- This transgene results from the coinjection of two constructs derived from diabetogenic T-cell clone BDC2.5. The Tcra construct contains a rearranged Tcra sequence (V alpha J alpha) that begins 20 bp 5' of the ATG site and ends 30 bp 3' of the splice donor sequence of J alpha 17. The 6.5 Tcrb construct contains rearranged Tcrb sequence (V beta D beta J beta) flanked by 2 kb of 5' regulatory sequences and 3.5 kb of 3' DNA containing the unrearranged J beta 1.3 to J beta 1.6 sequences, and precedes a 12 kb sequence containing the C beta 2 region.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- None
- Knock-down Targets
- None
- Regulatory Regions
- None