Allele/Variant

Itgaltm1Mak

Species
Mus musculus
Symbol
Itgaltm1Mak
Category
allele
Allele of gene
Itgal
Transgenic Constructs
None
Synonyms
  • CD11a -
  • LFA-1-
Description
Sequence encoding the signal peptide and the amino terminal extracellular domain (exons 2 through 6) was replaced with a neomycin selection cassette. Surface expression was undetected by FACS analysis of homozygous mutant B and T cells.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
decreased susceptibility to endotoxin shockMGI
impaired natural killer cell mediated cytotoxicity
MGI
increased circulating interleukin-10 level
MGI
increased circulating interleukin-2 level
MGI
increased circulating tumor necrosis factor level
MGI
thrombocytopenia
MGI
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Disease Associations

No data available