Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Col2a1-Fgfr3/GH)BDor
MGI:2181547Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Col2a1-Fgfr3/GH)BDor

Species
Mus musculus
Symbol
Tg(Col2a1-Fgfr3/GH)BDor
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • FGFR3ach
Description
The transgene consists a mouse cDNA of Fgfr3 which harbors a dominant mutation found in human achondroplasia (G380R). This sequence is fused to human growth hormone gene with a deletion in exon 5 to provide additional splice and polyadenylation sites.Expression of the transgene is targeted to cartilage tissue by promoter and enhancer sequences derived from rat type II collagen gene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
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