Nodal^tm2Rob

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Species

Mus musculus

Symbol

Nodal^tm2Rob

Category

allele

Allele of gene

Nodal

Transgenic Constructs

None

Synonyms

• Nodal^D600
• nodal^delta600

Description

By homologous recombination in ES cells heterozygous for the Nodal^tm1Rob allele, the entire 600 bp ASE enhancer region was replaced by a loxP-flanked hygromycin selection cassette in trans to the original mutation. Transient expression of Cre recombinase in targeted ES cells resulted in excision of the selection cassette, leaving a single loxP site in place of the enhancer sequences. Subsequent matings of mice carrying this allele resulted in segregation from the Nodal^tm1Rob allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations