Allele/Variant

Drgxtm1And

Species
Mus musculus
Symbol
Drgxtm1And
Category
allele
Allele of gene
Drgx
Transgenic Constructs
None
Synonyms
  • Drg11-
  • Prrxl1-
Description
Exons 3 and 4 were replaced with a IRES-Tau-lacZ-neo cassette via homologous recombination. The gene targeting event results in deletion of most of the paired-like homeodomain and putative DNA-binding domain. RT-PCR analysis of homozygous mutant animals was unable to detect gene transcription using primers to the gene coding region or neomycin resistance gene. Amplification products were obtained using primers to the lacZ gene, but lack of beta-gal activity suggests these transcripts were spliced abnormally.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations