Allele/Variant

Nfatc2tm1Glm

Species
Mus musculus
Symbol
Nfatc2tm1Glm
Category
allele
Allele of gene
Nfatc2
Transgenic Constructs
None
Synonyms
  • c2-
  • NF-ATp-mut
Description
A neomycin selection cassette replaced sequences encoding 47 amino acids of the Rel homology domain. An absence of normal protein in homozygous mutant mice was determined through Western blot analysis. Low levels of reactive polypeptides were present in the cytoplasm, however, no reactivity was observed in the nucleus. RT-PCR and sequence analysis revealed aberrantly spliced in-frame transcripts from which the targeted exon had been excised. An electrophoretic mobility shift assay confirmed that DNA was not binding to the mutant protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

No data available

Disease Associations

No data available