Allele/Variant

Epha8tm1Bbd

Species
Mus musculus
Symbol
Epha8tm1Bbd
Category
allele
Allele of gene
Epha8
Transgenic Constructs
None
Synonyms
  • ephA8/eek-
Description
The exon encoding the extracellular domain was replaced with sequence encoding the transmembrane domain of the human NTRK1 receptor followed by lacZ and neo genes. The deletion was designed to generate a chimeric protein in which the fibronectin type III-like domains were absent from the extracellular region, leaving only 116 carboxy terminal residues intact, and in which the entire cytoplasmic region was replaced by lacZ. LacZ activity was detected during embryonic stages and undetected during postnatal development.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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