Adcyap1^tm1Aba

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Species

Mus musculus

Symbol

Adcyap1^tm1Aba

Category

allele

Allele of gene

Adcyap1

Transgenic Constructs

None

Synonyms

• Adcyap^tm1Mok
• PACAP^-

Description

The gene was disrupted by replacement of the 5' portion of exon 5 with a PGK-neo cassette via homologous recombination. RT-PCR analysis using primers to exons 3-4 and exons 3-5 did not detect gene expression in the midbrain and diencephalons of homozygous mutant animals. In situ hybridization of parasagittal brain sections from homozygous mutants using a probe to the deleted portion of the gene did not detect gene expression. The null allele was further demonstrated by radioimmunoassay (RIA) of brain samples from homozygous mutant animals, which did not detect protein product.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations