Allele/Variant

Airetm1Pltn

Species
Mus musculus
Symbol
Airetm1Pltn
Category
allele
Allele of gene
Aire
Transgenic Constructs
None
Synonyms
  • Aire-
  • LA Aire -
Description
A neomycin resistance cassette replaced a genomic fragment containing part of exon 6. This mutation mimics a common human mutation of a termination codon in exon 6. RT-PCR analysis demonstrated that aberrant trasncripts were expressed, and immunohistochemisty experiments on sections of thymus liver and brain of homozygous mice confirmed that no detectable protein was made from this allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations