Elk3^tm1Wlyk

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Species

Mus musculus

Symbol

Elk3^tm1Wlyk

Category

allele

Allele of gene

Elk3

Transgenic Constructs

None

Synonyms

• net^delta
• Net^mutant

Description

Exon 2, which encodes the first 69 amino acids (including the initiator methionine), and surrounding intronic sequence were replaced with a neomycin selection cassette. RT-PCR and sequence analysis showed the presence of an aberrantly spliced transcript in which exon 1 had joined exon 3. The aberrant transcript was shown by Western blot analysis to produce a 37kDa protein via an in-frame translational start site at nucleotide 571 (aa 93). The mutant protein lacks the Ets DNA-binding domain.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations