Allele/Variant

Elk3tm1Wlyk

Species
Mus musculus
Symbol
Elk3tm1Wlyk
Category
allele
Allele of gene
Elk3
Transgenic Constructs
None
Synonyms
  • netdelta
  • Netmutant
Description
Exon 2, which encodes the first 69 amino acids (including the initiator methionine), and surrounding intronic sequence were replaced with a neomycin selection cassette. RT-PCR and sequence analysis showed the presence of an aberrantly spliced transcript in which exon 1 had joined exon 3. The aberrant transcript was shown by Western blot analysis to produce a 37kDa protein via an in-frame translational start site at nucleotide 571 (aa 93). The mutant protein lacks the Ets DNA-binding domain.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

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