Allele/Variant

Rasgrf2tm1Esn

Species
Mus musculus
Symbol
Rasgrf2tm1Esn
Category
allele
Allele of gene
Rasgrf2
Transgenic Constructs
None
Synonyms
  • grf2-
  • Rasgrf2-
Description
A portion of the CDC25-H domain, a highly conserved region of the gene, from amino acids 1005-1070 was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of brain RNA and absence of protein product was demonstrated by Western blot of brain and lung extracts using an antibody directed against a region of the protein upstream of the disruption.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations