Allele/Variant

Rasgrf2tm1Esn

Species
Mus musculus
Symbol
Rasgrf2tm1Esn
Category
allele
Allele of gene
Rasgrf2
Transgenic Constructs
None
Synonyms
  • grf2-
  • Rasgrf2-
Description
A portion of the CDC25-H domain, a highly conserved region of the gene, from amino acids 1005-1070 was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of brain RNA and absence of protein product was demonstrated by Western blot of brain and lung extracts using an antibody directed against a region of the protein upstream of the disruption.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
decreased interleukin-2 secretionMGI
decreased tumor necrosis factor secretionMGI
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Disease Associations