Rasgrf2^tm1Esn

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Species

Mus musculus

Symbol

Rasgrf2^tm1Esn

Category

allele

Allele of gene

Rasgrf2

Transgenic Constructs

None

Synonyms

• grf2^-
• Rasgrf2^-

Description

A portion of the CDC25-H domain, a highly conserved region of the gene, from amino acids 1005-1070 was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of brain RNA and absence of protein product was demonstrated by Western blot of brain and lung extracts using an antibody directed against a region of the protein upstream of the disruption.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations