Allele/Variant

Gfaptm1Pkny

Species
Mus musculus
Symbol
Gfaptm1Pkny
Category
allele
Allele of gene
Gfap
Transgenic Constructs
None
Synonyms
  • GFAP-
Description
The insertion of a neomycin selection cassette deleted 2.0kb of the upstream regulatory region as well as sequence in exon 1 encoding the first 71 amino acids. Northern blot analysis of total brain RNA showed a lack of transcript produced from this allele. Encoded protein was undetected in homozygous mutant mice via immunohistochemical staining of astrocytes.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations