Tnfrsf11a^tm1Wjb

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Species

Mus musculus

Symbol

Tnfrsf11a^tm1Wjb

Category

allele

Allele of gene

Tnfrsf11a

Transgenic Constructs

None

Synonyms

• RANK^-

Description

A portion of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. The deleted region encoded approximately one and one half of the amino-terminal TNFR-like cysteine-rich domain, comprised of residues 34 through 96. Northern blot analysis confirmed the absence of normal transcript, while the results of a Western blot analysis of intestinal lysates using antibodies raised against the extracellular domain of the endogenous protien indicated a lack of protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations