Mdm4^tm1Glo

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Species

Mus musculus

Symbol

Mdm4^tm1Glo

Category

allele

Allele of gene

Mdm4

Transgenic Constructs

None

Synonyms

• Mdm4^-

Description

Exons 3 through 5 were replaced with a neomycin selection cassette. The deleted region encoded the majority of the Trp53-binding domain (amino acids 27-96). Aberrant splicing around the neo transgene would result in a frameshift mutation. Protein was undetected in homozygous mutant mice by Western blot analysis.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations