Mbd4^tm1Bird

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Species

Mus musculus

Symbol

Mbd4^tm1Bird

Category

allele

Allele of gene

Mbd4

Transgenic Constructs

None

Synonyms

• Mbd4^-

Description

A cassette, containing a splice acceptor site and IRES-Beta-geo, was inserted into intron 1 of the endogenous locus. Northern blot and RT-PCR analysis showed levels of transcript in homozygous mutant mice to be less than 0.1% of those in wild-type mice. Two truncated transcripts were identified; one which truncated at the transgenic polyadenylation signal and another in which a frameshift mutation was introduced by the excision of the IRES-Beta-geo transgenic region (leaving the the splice acceptor site in between exons 1 and 2).

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations