Allele/Variant

Tg(APPSWE)2123Kha

Species

Mus musculus

Symbol

Tg(APPSWE)2123Kha

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

Tg(APP*Swe)2123Kha
Tg(APPSWE)2123HKahs

Description

Overexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. This transgenic line was estimated to contain ~31 copies of the transgene. Other lines generated using this construct varied in copy number and severity of phenoytpe.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

APP (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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