Timp3^tm1Web

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Species

Mus musculus

Symbol

Timp3^tm1Web

Category

allele

Allele of gene

Timp3

Transgenic Constructs

None

Synonyms

• Timp3^S156C
• Timp3^S179C

Description

Site-directed mutagenesis of codon 179 (exon 5; older nomenclature is S156C) resulted in a serine to cysteine substitution. A floxed neomycin selection cassette inserted into intro 4 was excised via the in vitro expression of cre recombinase. Sequence analysis showed that a normal sized transcript detected by Northern blot and RT-PCR analyses contained the desired missense mutation. Western blot analysis of ECM protein extracts confirmed proper translation of the mutant transcript.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations