Ercc2^tm1Jhjh

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Species

Mus musculus

Symbol

Ercc2^tm1Jhjh

Category

allele

Allele of gene

Ercc2

Transgenic Constructs

None

Synonyms

• TTD-
• XPD⁰

Description

All of exons 17 through 21 and a portion of exon 22 were replaced by a cassette containing neo and hprt transgenes. The insertion is upstream of sequence encoding the DNA helicase domains 4 through 6 and the putative DNA-binding domain. The potential excision of the cassette generates a frameshift mutation via the splicing of exons 16 and 23. The targeting vector was designed such that it would not interfere with the Klc3 locus on the antisense strand.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations