Cd55^tm1Mme

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Species

Mus musculus

Symbol

Cd55^tm1Mme

Category

allele

Allele of gene

Cd55

Transgenic Constructs

None

Synonyms

• Cd55^-
• Daf1^-

Description

A loxP site was introduced with a neo-TK cassette into exon 3 and a second loxP site was introduced with a TK-Hph cassette into exon 5 via homologous recombination. Transient expression of cre recombinase in correctly targeted ES cells removed floxed regions containing exons 3-5 and the 2 TK genes. The deleted exons encode complement control protein (CCP) modules 2 and 3. RT-PCR analysis detected a truncated mRNA in homozygous mutant animals lacking exons 3-5. Functional assays confirmed the mutant protein was devoid of protein activity.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations