Flt3^tm1Irl

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Species

Mus musculus

Symbol

Flt3^tm1Irl

Category

allele

Allele of gene

Flt3

Transgenic Constructs

None

Synonyms

• Flk2^-

Description

Exon 3 was disrupted by the insertion of a neomycin selection cassette at the codon corresponding to residue 59 in the mature protein. An RNAse protection assay detected low levels of transcript in homozygous mutant mice. RT-PCR and sequence analyses of the mutant transcript showed that the targeted exon 3 had been excised, resulting in a frameshift mutation that introduces a stop codon after codon 51.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations