Allele/Variant

Cd3etm1.1Lov

Species
Mus musculus
Symbol
Cd3etm1.1Lov
Category
allele
Allele of gene
Cd3e
Transgenic Constructs
None
Synonyms
  • Cd3e-
  • Cd3edelta
Description
This allele was generated by breeding mice homozygous for Cd3etm1Lov with transgenic mice expressing cre recombinase via the EIIa promoter, resulting in the excision of the floxed neo. Northern blot analysis of homozygous mutant mice showed normal levels of Cd3d and Cd3g transcript as well as the presence of a truncated Cd3e transcript. Sequencing of Cd3e cDNA derived from RT-PCR analysis showed the splicing of exons 4 to 7 (lacking the extracellular and transmembrane domains). Western blot analysis showed the absence of truncated protein product.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations