Version: 8.0.0
Date: Tue Jan 28 2025
Il4tm1Rao
MGI:2384290
Allele of Il4
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Il4tm1Rao

Species
Mus musculus
Symbol
Il4tm1Rao
Category
allele
Allele of gene
Il4
Transgenic Constructs
None
Synonyms
  • Rr168tm1Rao
  • V/Va KO
Description
3.7 kb of sequence in the intergenic region between Il4 and Kif3a was replaced with a loxP site flanked neomycin resistance gene cassette. The deleted region contains DNAse I hypersensitivity sites V and Va. These sites contain enhancers for Il4 transcription. The neo cassette was excised in vitro via the expression of cre recombinase. T lymphocytes and mast cells from homozygous mutant mice express severely reduced Il4 mRNA and protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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